Dynamic Loading of Human Engineered Heart Tissue Enhances Contractile Function and Drives a Desmosome-linked Disease Phenotype

Jacqueline M. Bliley, Mathilde C. S. C. Vermeer, Rebecca M. Duffy, Ivan Batalov, Duco Kramer, Joshua W. Tashman, Daniel J. Shiwarski, Andrew Lee, Alexander S. Teplenin, Linda Volkers, Brian Coffin, Martijn F. Hoes, Anna Kalmykov, Rachelle N. Palchesko, Yan Sun, Jan D. H. Jongbloed, Nils Bomer, Rudolf A. de Boer, Albert J. H. Suurmeijer, Daniel A. Pijnappels, Maria C. Bolling, Peter van der Meer*, and Adam W. Feinberg are co-authors on our recent publication in Science Translational Medicine titled “Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype.” Here, we use a novel dynamic engineered heart tissue (dyn-EHT) system to model arrhythmogenic cardiomyopathy.

Read the article in Science Translational Medicine.

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