News – Page 2 – Regenerative Biomaterials & Therapeutics Group

November 18, 2020October 20, 2021

Fibronectin-Based Nanomechanical Biosensors to Map 3D Strains in Live Cells and Tissue

Dan Shiwarski, Josh Tashman, Alkiviadis Tsamis, Jaci Bliley, Malachi Blundon, Edgar Aranda-Michel, Quentin Jallerat, John Szymanski, Brooke McCartney and Adam Feinberg are co-authors on our recent article in Nature Communications entitled “Fibronectin-Based Nanomechanical Biosensors to Map 3D Strains in Live Cells and Tissues.” The ability to measure strain in cells and tissues in vitro with minimal perturbation and at high spatial resolution has proven challenging. Here, we have developed a fluorescently-labelled nanomechanical biosensor (NMBS) made of a fibronectin square lattice mesh with tunable resolution that can be applied to the surface of cells and tissues to enable direct quantification and mapping of strain over time. Additionally, we have released an open-source MATLAB and Imaris biomechanics software package to map and quantify 3D surface strain, cardiomyocyte beat frequency, and area dilation from live fluorescence imaging data. Accompanying the manuscript is a published protocol detailing the step-by-step NMBS fabrication process.

Read the article at Nature Communications

October 23, 2020November 23, 2020

FRESH 3D Bioprinting a Full-Size Model of the Human Heart

Eman Mirdamadi, Josh Tashman, Dan Shiwarski, Rachelle Palchesko, and Adam Feinberg are co-authors on our recent article in ACS Biomaterials Science & Engineering entitled “FRESH 3D Bioprinting a Full-Size Model of the Human Heart.” In the article, we demonstrate the FRESH platform’s capabilities in printing acellular, full-sized human heart models from alginate, which possesses similar mechanical properties to cardiac tissue, enabling surgeons to one day use our models for realistic surgical simulation.

Read the article at ACS Biomaterials Science & Engineering

October 1, 2020October 20, 2021

Congratulations to Undergraduate Researcher Sanjana Shah for receiving the Andrew Carnegie Scholarship

ACS Scholars are undergraduate seniors who embody the University’s high standards of academic excellence, volunteerism, leadership and involvement in student organizations, athletics or the arts. The winners of the ACS Scholars program are carefully selected each year by deans/department heads from across Carnegie Mellon. Congratulations Sanjana, click here to read more!

May 1, 2020November 23, 2020

Congratulations to Eman Mirdamadi (Master’s Student) and Xining Gao (Undergraduate) for choosing PhD programs

Previous RBG lab members Eman Mirdamadi (Master’s student, 2018-2020) and Xining Gao (undergraduate researcher, 2017-2020) accept offers to PhD programs at UMD and Harvard/MIT, respectively (April 2020). Goodluck to Eman and Xining on their future endeavors; we are so proud!

April 16, 2020November 23, 2020

Congratulations to Emily Sevcik for Receiving Her PhD

Congratulations to Dr. Emily Sevcik for receiving her PhD in Biomedical Engineering. Her dissertation is titled “Understanding Fibronectin Mechanobiology of Growth Factor Binding Domain Availability and Cellular Extracellular Matrix Remodeling.” Her research has been published in Current Protocols in Cell Biology and Biomaterials Science. Emily was a pivotal member of the lab and will be greatly missed!

March 31, 2020November 23, 2020

Congratulations to undergraduate Xining Gao for receiving the NSF GRFP!

Congratulations to Xining Gao, an undergraduate researcher in the RBG group, who has received the prestigious National Science Foundation (NSF) Graduate Research Fellowship Program (GFRP). Xining is a dual major in Biomedical Engineering (BME) and Material Science Engineering (MSE), who will graduate in May 2020, and plans to continue her education after graduation as a PhD student in BME. We are so excited to see what she will accomplish!

March 11, 2020November 23, 2020

Feinberg Lab is awarded a grant from the DARPA BETR project involving “smart” wound healing

The Feinberg Lab is awarded a grant from the Defense Advanced Research Projects Agency’s (DARPA) Bioelectronics for Tissue Regeneration (BETR) project for the repair of volumetric muscle loss. The Feinberg lab will work in collaboration with labs from Carnegie Mellon University, University of Pittsburgh, Northwestern University, the University of Vermont, the University of Wisconsin and Walter Reed National Military Medical Center to generate the Regenerative Electronics Platform through Advanced Intelligent Regulation (REPAIR) patch, designed to help regrow fully functional muscle tissue. Click here to read more about this project.

January 31, 2020November 22, 2020

Congratulations to Jaci Bliley, who is awarded CMU’s Presidential Scholarship

Jaci Bliley is awarded a Presidential Scholarship through CMU’s Presidential Fellowship Program, which is intended to award excellence and encourage impactful research by Ph.D. students.

October 28, 2019November 22, 2020

Congratulations to Jaci Bliley for “Best Oral Presentation” at Biomaterials Day

Jaci received 1st place for “Best Oral Presentation” at Biomaterials Day at Case Western Reserve University. Her talk was titled “Perfused 3D Printed Collagen Tubes Support Tissue Viability.”

September 11, 2019November 23, 2020

Congratulations to Andrew Lee for Receiving his PhD

Congratulations to Dr. Andrew Lee for receiving his PhD in Biomedical Engineering. His dissertation is titled “3D Bioprinting of Collagen to Engineer Muscle Tissues with Complex Architectures.” Andrew has received a number of awards and recognitions as a PhD student in the group. His research has been published in Science and ACS Biomaterials Science & Engineering. Andrew is continuing his career as the Head of Bioprinting at FluidForm.