Emily Sevcik, John Szymanksi and Quentin Jallerat are co-authors on our recent article in Current Protocols in Cell Biology entitled “Patterning on Topography for Generation of Cell Culture Substrates with Independent Nanoscale Control of Chemical and Topographical Extracellular Matrix Cues.” In the article we provide detailed methods on how to perform our Patterning on Topography (PoT) technology to independently pattern extracellular matrix proteins on topographically complex surfaces for studying cell-material interactions.
John Szymanksi, Emily Sevcik and Kairui Zhang are co-authors on our recent article in Biomaterials Science entitled “Stretch-dependent changes in molecular conformation in fibronectin nanofibers.” This article is part of the Biomaterials Science Emerging Investigators 2017 issue of the journal. In the article we used AFM imaging of fibronectin nanofibers over a wide range of deformations to understand how reversible molecular unfolding contributes to the mechanical properties of extracellular matrix proteins.
John Szymanksi and Kairui Zhang are co-authors on our recent article in Scientific Reports entitled “Measuring the Poisson’s Ratio of Fibronectin Using Engineered Nanofibers.” This article used AFM imaging of fibronection nanofibers over a wide range of deformations to show that volume is conserved, thus behaving as an elastic material with a Poisson’s ratio of ~0.5.
Congratulations to Dr. TJ Hinton for receiving his PhD in Biomedical Engineering. His dissertation is titled “Rapid Prototyping Tissue Models of Mammary Duct Epithelium.” TJ has received a number of awards and recognitions as a PhD student in the group including the Bertucci Fellowship from the Carnegie Institute of Technology. His research has been published in Science Advances, ACS Biomaterials Science & Engineering and Current Opinion in Biomedical Engineering. TJ is continuing his career as a postdoctoral fellow in our lab, supported by a prestigious Swartz Innovation Fellow to help commercialize our 3D bioprinting FRESH technology.
Congratulations to Dr. Ivan Batalov for receiving his PhD in Materials Science & Engineering. His dissertation is titled “Engineering 2D Cardiac Tissues Using Biomimetic Protein Micropatterns Based on the Extracellular Matrix in the Embryonic Heart.” Ivan is continuing his career as a postdoctoral fellow in the labs of Kelly Stevens and Cole DeForest at the University of Washington.
Congratulations to Dr. Rebecca Duffy for receiving her PhD in Biomedical Engineering. Her dissertation is titled “Engineering Contractile 2D and 3D Human Skeletal and Cardiac Muscle Microtissues.” Rebecca has received a number of awards and recognitions as a PhD student in the group including the Bertucci Fellowship from the Carnegie Institute of Technology. Her research has been published in Acta Biomaterialia and Annals of Biomedical Engineering. Rebecca will be continuing her career as a postdoctoral fellow in the lab of Linda Griffith at MIT.
Congratulations to Dr. Quentin Jallerat for receiving his PhD in Biomedical Engineering. His dissertation is titled “An Embryonic-inspired Approach to Engineer Functional Human Cardiac Tissue.” Quentin has received a number of awards and recognitions as a PhD student in the group including the Dowd-ICES Fellowship and the Richard King Mellon Foundation Presidential Fellowship in the Life Sciences, the Graduate Student Award for Outstanding Teaching Assistant and STAR Award for Best Abstract from the Society for Biomaterials. His research has been published in Science Advances and Nature Methods. Quentin will be continuing his career in the healthcare consulting field.
TJ Hinton, Andrew Hudson, Kira Pusch and Andrew Lee are co-authors on our recent article in ACS Biomaterials Science & Engineering entitled “3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding.” This article describes a new technique termed Freeform Reversible Embedding (FRE) to 3D print polydimethysiloxane (PDMS) elastomer such as Sylgard 184 in complex 3D structures within a hydrophilic Carbopol support. Unique is the ability to 3D print PDMS that takes hours to days to cure, demonstrating the capability to 3D print fluidic materials and decoupling the gelation and curing of the polymer from its ability to be 3D printed.
Prarthana Patil and John Szymanski are co-authors on our recent article in Advanced Materials Technologies entitled “Defined Micropatterning of ECM Protein Adhesive Sites on Alginate Microfibers for Engineering Highly Anisotropic Muscle Cell Bundles.” This article describes a new technique to selectively pattern ECM protein adhesive sites on alginate microfibers to engineer muscle tissue bundles. Unique is the ability of the ribbon-like microfibers to wrap around the muscle cells and form a basal lamina like structure.