Regenerative Biomaterials & Therapeutics Group
Prof. Adam Feinberg | Biomedical Engineering | Materials Science & Engineering | Carnegie Mellon University
We have published an article entitled “Fabrication of Freestanding Alginate Microfibers and Microstructures for Tissue Engineering Applications” in the journal Biofabrication . Authors are graduate student John Szymanski and Prof Adam Feinberg.
We have published a review article entitled “Engineered skeletal muscle tissue for soft robotics: fabrication strategies, current applications, and future challenges” in the journal WIREs Nanomedicine and Nanobiotechnology. Authors are graduate student Rebecca Duffy and Prof Adam Feinberg.
Prof. Feinberg is the lead author on a new publication in the journal Stem Cell Reports describing the functional comparison of cardiac muscle engineered from neonatal mouse cardiomyocytes versus cardiomyocytes derived from mouse embryonic stem cells. The study highlights the functional immaturity of stem cell derived cardiomyocytes in terms of electrophysiology and contractility at the tissue scale.
We have published a book chapter entitled “Nanofiber Biomaterials” in the Springer Handbook of Nanomaterials covering the fabrication, characterization and application of nanofiber biomaterials. Congratulations to Rachelle, Yan, Ling, John and Quentin!
We have published a new article in the journal Acta Biomaterialia on tissue engineered skeletal muscle entitled “Optimizing the Structure and Contractility of Engineered Skeletal Muscle Thin Films.” Congratulations to Yan, Rebecca and Ashley for publishing the second research paper from the group!
We have published a new article in the journal PLoS ONE on substrates with tunable elastic modulus entitled “Development of Polydimethylsiloxane Substrates with Tunable Elastic Modulus to Study Cell Mechanobiology in Muscle and Nerve.”
Prof. Feinberg is a coauthor on a new publication in Nature Biotechnology on the tissue engineering of a synthetic organism, an artificial “jellyfish.” This work was led by PhD student Janna Nawroth at Caltech and a collaboration of scientists from Caltech and Harvard. This is a fantastic example of how simple components (an elastic sheet and muscle cells) can be combined to enable the emergence of complex swimming behavior that mimics really jellyfish.
Read more:
Go to the paper at Nature Biotechnology
Harvard press release
Nature news release
Discover Magazine article
Dr. Feinberg has authored a research article entitled “Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture” in the journal Biomaterials. This article describes the use of engineered, matrix encoded boundary conditions to control the assembly and contractile function of engineered heart muscle. The results have important implications in how to maximize the physiologic function of engineered tissues.
This video shows examples of how controlling the alignment of the heart muscle cells can dramatically increase the contractile force these engineered tissues generate.
Dr. Feinberg has authored a review article entitled “Engineered tissue grafts: opportunities and challenges in regenerative medicine” in the journal Wiley Interdisciplinary Reviews: Systems Biology and Medicine.
Dr. Feinberg is a co-author on the recently published article entitled “Hierarchical architecture influences calcium dynamics in engineered cardiac muscle” in the Experimental Biology and Medicine.
Pong, T., W. J. Adams, et al. (2011). “Hierarchical architecture influences calcium dynamics in engineered cardiac muscle.” Proceedings Of The Society For Experimental Biology And Medicine: ebm.2010.010239.
http://ebm.rsmjournals.com/cgi/content/abstract/ebm.2010.010239v1