Publication: “Functional Differences in Engineered Myocardium from Embryonic Stem Cell-Derived versus Neonatal Cardiomyocytes”

Prof. Feinberg is the lead author on a new publication in the journal Stem Cell Reports describing the functional comparison of cardiac muscle engineered from neonatal mouse cardiomyocytes versus cardiomyocytes derived from mouse embryonic stem cells.  The study highlights the functional immaturity of stem cell derived cardiomyocytes in terms of electrophysiology and contractility at the tissue scale.

“Functional Differences in Engineered Myocardium from Embryonic Stem Cell-Derived versus Neonatal Cardiomyocytes”

Publication: A tissue-engineered jellyfish with biomimetic propulsion

Prof. Feinberg is a coauthor on a new publication in Nature Biotechnology on the tissue engineering of a synthetic organism, an artificial “jellyfish.”  This work was led by PhD student Janna Nawroth at Caltech and a collaboration of scientists from Caltech and Harvard.  This is a fantastic example of how simple components (an elastic sheet and muscle cells) can be combined to enable the emergence of complex swimming behavior that mimics really jellyfish.

 

Read more:
Go to the paper at Nature Biotechnology
Harvard press release
Nature news release
Discover Magazine article 

 

 

Publication: Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture

Dr. Feinberg has authored a research article entitled “Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture” in the journal Biomaterials.  This article describes the use of engineered, matrix encoded boundary conditions to control the assembly and contractile function of engineered heart muscle.  The results have important implications in how to maximize the physiologic function of engineered tissues.

This video shows examples of how controlling the alignment of the heart muscle cells can dramatically increase the contractile force these engineered tissues generate.

Engineered Cardiac Muscle

Hierarchical architecture influences calcium dynamics in engineered cardiac muscle

Dr. Feinberg is a co-author on the recently published article entitled “Hierarchical architecture influences calcium dynamics in engineered cardiac muscle” in the Experimental Biology and Medicine.

Pong, T., W. J. Adams, et al. (2011). “Hierarchical architecture influences calcium dynamics in engineered cardiac muscle.” Proceedings Of The Society For Experimental Biology And Medicine: ebm.2010.010239.
http://ebm.rsmjournals.com/cgi/content/abstract/ebm.2010.010239v1