Dr. Feinberg has authored a research article entitled “Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture” in the journal Biomaterials. This article describes the use of engineered, matrix encoded boundary conditions to control the assembly and contractile function of engineered heart muscle. The results have important implications in how to maximize the physiologic function of engineered tissues.
This video shows examples of how controlling the alignment of the heart muscle cells can dramatically increase the contractile force these engineered tissues generate.
Engineered Cardiac Muscle
Dr. Feinberg has authored a review article entitled “Engineered tissue grafts: opportunities and challenges in regenerative medicine” in the journal Wiley Interdisciplinary Reviews: Systems Biology and Medicine.
Dr. Feinberg is a co-author on the recently published article entitled “Hierarchical architecture influences calcium dynamics in engineered cardiac muscle” in the Experimental Biology and Medicine.
Pong, T., W. J. Adams, et al. (2011). “Hierarchical architecture influences calcium dynamics in engineered cardiac muscle.” Proceedings Of The Society For Experimental Biology And Medicine: ebm.2010.010239.