{"id":1756,"date":"2021-07-22T13:29:00","date_gmt":"2021-07-22T20:29:00","guid":{"rendered":"https:\/\/regenerativebiomaterials.com\/?p=1756"},"modified":"2021-10-20T13:40:28","modified_gmt":"2021-10-20T20:40:28","slug":"gain-of-function-mutation-in-ubiquitin-ligase-klhl24-causes-desmin-degradation-and-dilatation-in-hipsc-derived-engineered-heart-tissues","status":"publish","type":"post","link":"https:\/\/regenerativebiomaterials.com\/wordpress\/?p=1756","title":{"rendered":"Gain-of-function Mutation in Ubiquitin Ligase KLHL24 Causes Desmin Degradation and Dilatation in hiPSC-Derived Engineered Heart Tissues"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/regenerativebiomaterials.com\/wordpress\/wp-content\/uploads\/2021\/10\/JCI140615.ga-1.jpg\" alt=\"\" class=\"wp-image-1758\" width=\"517\" height=\"429\" srcset=\"https:\/\/regenerativebiomaterials.com\/wordpress\/wp-content\/uploads\/2021\/10\/JCI140615.ga-1.jpg 700w, https:\/\/regenerativebiomaterials.com\/wordpress\/wp-content\/uploads\/2021\/10\/JCI140615.ga-1-300x249.jpg 300w\" sizes=\"(max-width: 517px) 100vw, 517px\" \/><\/figure><\/div>\n\n\n\n<p>Mathilde C.S.C. Vermeer<sup>,<\/sup>\u00a0Maria C. Bolling,\u00a0<strong>Jacqueline M. Bliley<\/strong>,\u00a0Karla F. Arevalo Gomez,\u00a0Mario G. Pavez-Giani,\u00a0Duco Kramer,\u00a0Pedro H. Romero-Herrera,\u00a0B. Daan Westenbrink,\u00a0Gilles F.H. Diercks,\u00a0Maarten P. van den Berg,<sup>1<\/sup>\u00a0<strong>Adam W. Feinberg<\/strong>,\u00a0Herman H.W. Sillj\u00e9,\u00a0and\u00a0Peter van der Meer are co-authors on a recent publication in <strong><em>The Journal of Clinical Investigation<\/em><\/strong> titled &#8220;Gain-of-function Mutation in Ubiquitin Ligase KLHL24 Causes Desmin Degradation and Dilatation in hiPSC-Derived Engineered Heart Tissues.&#8221;<a href=\"https:\/\/www.jci.org\/articles\/view\/140615\"> Here<\/a>, the authors use the dynamically loaded engineered heart tissue (dyn-EHT) system to model dilated cardiomyopathy in patients with a KLHL24 mutation.<br><br><strong><a href=\"https:\/\/www.jci.org\/articles\/view\/140615\">Read the article in The Journal of Clinical Investigation. <\/a><\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mathilde C.S.C. Vermeer,\u00a0Maria C. Bolling,\u00a0Jacqueline M. Bliley,\u00a0Karla F. Arevalo Gomez,\u00a0Mario G. Pavez-Giani,\u00a0Duco Kramer,\u00a0Pedro H. Romero-Herrera,\u00a0B. Daan Westenbrink,\u00a0Gilles F.H. Diercks,\u00a0Maarten P. van den Berg,1\u00a0Adam W. Feinberg,\u00a0Herman H.W. Sillj\u00e9,\u00a0and\u00a0Peter van der Meer are co-authors on a recent publication in The Journal of Clinical Investigation titled &#8220;Gain-of-function Mutation in Ubiquitin Ligase KLHL24 Causes Desmin Degradation and Dilatation in &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/regenerativebiomaterials.com\/wordpress\/?p=1756\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Gain-of-function Mutation in Ubiquitin Ligase KLHL24 Causes Desmin Degradation and Dilatation in hiPSC-Derived Engineered Heart Tissues&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,5],"tags":[],"_links":{"self":[{"href":"https:\/\/regenerativebiomaterials.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1756"}],"collection":[{"href":"https:\/\/regenerativebiomaterials.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/regenerativebiomaterials.com\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/regenerativebiomaterials.com\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/regenerativebiomaterials.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1756"}],"version-history":[{"count":1,"href":"https:\/\/regenerativebiomaterials.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1756\/revisions"}],"predecessor-version":[{"id":1759,"href":"https:\/\/regenerativebiomaterials.com\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1756\/revisions\/1759"}],"wp:attachment":[{"href":"https:\/\/regenerativebiomaterials.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1756"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/regenerativebiomaterials.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1756"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/regenerativebiomaterials.com\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1756"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}