Looking for a Postdoctoral Research Associate in the Regenerative Biomaterials and Therapeutics Group!

The Regenerative Biomaterials and Therapeutics Group is looking for a Postdoctoral Researcher who will work on independent experimentation and/or directed research to achieve better understanding on cell engraftment into tight-junctioning epithelial cells. This position requires and in-depth knowledge of pseudo-stratified epithelial cell layers, particularly related to the lung. Tasks in this position may include organizing, implementing, and analyzing data collected from, experiments involving live human cells, explanted animal tissue, and in vivo live animal studies. Please click here to apply!

Congratulations for Jaci Bliley for successfully defending her thesis and receiving her PhD!

Congrats to Dr. Jaci Bliley for successfully presenting her thesis defense titled “Mechanical Loading of Engineered Heart Muscle Tissues for Disease Modeling and Repair of the Human Heart“. Dr. Bliley is an extremely accomplished researcher who has published a many ground-breaking papers, including papers published in Science and Science Translational Medicine. We are so lucky to have you as part of the lab and are so excited to see all you will accomplish in your future! Congrats again Dr. Bliley.

Gain-of-function Mutation in Ubiquitin Ligase KLHL24 Causes Desmin Degradation and Dilatation in hiPSC-Derived Engineered Heart Tissues

Mathilde C.S.C. Vermeer, Maria C. Bolling, Jacqueline M. Bliley, Karla F. Arevalo Gomez, Mario G. Pavez-Giani, Duco Kramer, Pedro H. Romero-Herrera, B. Daan Westenbrink, Gilles F.H. Diercks, Maarten P. van den Berg,1 Adam W. Feinberg, Herman H.W. Silljé, and Peter van der Meer are co-authors on a recent publication in The Journal of Clinical Investigation titled “Gain-of-function Mutation in Ubiquitin Ligase KLHL24 Causes Desmin Degradation and Dilatation in hiPSC-Derived Engineered Heart Tissues.” Here, the authors use the dynamically loaded engineered heart tissue (dyn-EHT) system to model dilated cardiomyopathy in patients with a KLHL24 mutation.

Read the article in The Journal of Clinical Investigation.

Dynamic Loading of Human Engineered Heart Tissue Enhances Contractile Function and Drives a Desmosome-linked Disease Phenotype

Jacqueline M. Bliley, Mathilde C. S. C. Vermeer, Rebecca M. Duffy, Ivan Batalov, Duco Kramer, Joshua W. Tashman, Daniel J. Shiwarski, Andrew Lee, Alexander S. Teplenin, Linda Volkers, Brian Coffin, Martijn F. Hoes, Anna Kalmykov, Rachelle N. Palchesko, Yan Sun, Jan D. H. Jongbloed, Nils Bomer, Rudolf A. de Boer, Albert J. H. Suurmeijer, Daniel A. Pijnappels, Maria C. Bolling, Peter van der Meer*, and Adam W. Feinberg are co-authors on our recent publication in Science Translational Medicine titled “Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype.” Here, we use a novel dynamic engineered heart tissue (dyn-EHT) system to model arrhythmogenic cardiomyopathy.

Read the article in Science Translational Medicine.

Congratulations to Joshua Tashman for receiving his PhD!

Congrats to Joshua Tashman for receiving his PhD and successfully defending his thesis on “Moving FRESH Towards the Clinic: In-Process Quality Control of Patient-Specific ECM Scaffolds“. Dr. Tashman is a MSTP Student through UPitt-CMU who will also be receiving his MD in addition to his PhD- a future Dr. Doctor! He is an incredible researcher who has published a multitude of papers and received the prestigious NIH F30 fellowship.
Goodluck to Dr. Tashman as he finishes up his medical degree!

Engineering Aligned Human Cardiac Muscle Using Developmentally Inspired Fibronectin Micropatterns

Ivan Batalov, Quentin Jallerat, Sean Kim, Jacqueline Bliley and Adam W. Feinberg are co-authors on our recent paper published in Nature Scientific Reports titled “Engineering aligned human cardiac muscle using developmentally inspired fibronectin micropatterns.” Here, we sought to use developmentally inspired cardiac micropatterns to better understand cardiomyocyte alignment.

Read the article in Nature Scientific Reports