Congratulations for Jaci Bliley for successfully defending her thesis and receiving her PhD!

Congrats to Dr. Jaci Bliley for successfully presenting her thesis defense titled “Mechanical Loading of Engineered Heart Muscle Tissues for Disease Modeling and Repair of the Human Heart“. Dr. Bliley is an extremely accomplished researcher who has published a many ground-breaking papers, including papers published in Science and Science Translational Medicine. We are so lucky to have you as part of the lab and are so excited to see all you will accomplish in your future! Congrats again Dr. Bliley.

Congratulations to Joshua Tashman for receiving his PhD!

Congrats to Joshua Tashman for receiving his PhD and successfully defending his thesis on “Moving FRESH Towards the Clinic: In-Process Quality Control of Patient-Specific ECM Scaffolds“. Dr. Tashman is a MSTP Student through UPitt-CMU who will also be receiving his MD in addition to his PhD- a future Dr. Doctor! He is an incredible researcher who has published a multitude of papers and received the prestigious NIH F30 fellowship.
Goodluck to Dr. Tashman as he finishes up his medical degree!

Fibronectin-Based Nanomechanical Biosensors to Map 3D Strains in Live Cells and Tissue

Dan Shiwarski, Josh Tashman, Alkiviadis Tsamis, Jaci Bliley, Malachi Blundon, Edgar Aranda-Michel, Quentin Jallerat, John Szymanski, Brooke McCartney and Adam Feinberg are co-authors on our recent article in Nature Communications entitled “Fibronectin-Based Nanomechanical Biosensors to Map 3D Strains in Live Cells and Tissues.” The ability to measure strain in cells and tissues in vitro with minimal perturbation and at high spatial resolution has proven challenging. Here, we have developed a fluorescently-labelled nanomechanical biosensor (NMBS) made of a fibronectin square lattice mesh with tunable resolution that can be applied to the surface of cells and tissues to enable direct quantification and mapping of strain over time. Additionally, we have released an open-source MATLAB and Imaris biomechanics software package to map and quantify 3D surface strain, cardiomyocyte beat frequency, and area dilation from live fluorescence imaging data. Accompanying the manuscript is a published protocol detailing the step-by-step NMBS fabrication process.

Read the article at Nature Communications

FRESH 3D Bioprinting a Full-Size Model of the Human Heart

Eman Mirdamadi, Josh Tashman, Dan Shiwarski, Rachelle Palchesko, and Adam Feinberg are co-authors on our recent article in ACS Biomaterials Science & Engineering entitled “FRESH 3D Bioprinting a Full-Size Model of the Human Heart.” In the article, we demonstrate the FRESH platform’s capabilities in printing acellular, full-sized human heart models from alginate, which possesses similar mechanical properties to cardiac tissue, enabling surgeons to one day use our models for realistic surgical simulation.

Read the article at ACS Biomaterials Science & Engineering

Congratulations to Undergraduate Researcher Sanjana Shah for receiving the Andrew Carnegie Scholarship

ACS Scholars are undergraduate seniors who embody the University’s high standards of academic excellence, volunteerism, leadership and involvement in student organizations, athletics or the arts. The winners of the ACS Scholars program are carefully selected each year by deans/department heads from across Carnegie Mellon. Congratulations Sanjana, click here to read more!

Congratulations to Emily Sevcik for Receiving Her PhD

Congratulations to Dr. Emily Sevcik for receiving her PhD in Biomedical Engineering. Her dissertation is titled “Understanding Fibronectin Mechanobiology of Growth Factor Binding Domain Availability and Cellular Extracellular Matrix Remodeling.” Her research has been published in Current Protocols in Cell Biology and Biomaterials Science. Emily was a pivotal member of the lab and will be greatly missed!